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Switch type:
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Physicochemical compatibility

Binding of the BIR domain-binding motif of Caspase-1 (Dcp-1) to the BIR domains of Apoptosis 1 inhibitor (th) requires cleavage of Caspase-1 (Dcp-1) at D33, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

(1) Caspase-1 (Dcp-1)
(2) Apoptosis 1 inhibitor (th)

Interaction #1 Dcp-1 - th

(1) LIG_BIR_III_4 motif (33DAKGC37) in Caspase-1 (Dcp-1)
(2) Inhibitor of Apoptosis domain (47-111) in Apoptosis 1 inhibitor (th)

Interaction Regulation
PTM-dependent Induction (Proteolytic cleavage at D33 on Caspase-1 (Dcp-1)) of the Caspase-1 (Dcp-1) LIG_BIR_III_4 motif - Apoptosis 1 inhibitor (th) Inhibitor of Apoptosis domain interaction

Switch localisation
ELM curated: cytosol, mitochondrion

(1) IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.
Tenev et al. Nat. Cell Biol. (2005)

See also

Other switches involving participants
Apoptosis 1 inhibitor (th) - 1 more (view)

Other switches involving interfaces
Inhibitor of Apoptosis domain - 8 more (view)
LIG_BIR_III_4 - 1 more (view)

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