Switch #: SWTI000535

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the di-leucine endocytosis motif of PEX5-related protein (Pex5l), abrogating binding to AP-2 complex subunit sigma (Ap2s1). The motif is present in exon 5.

Participants:
(1) PEX5-related protein (Pex5l)
(2) AP-2 complex subunit sigma (Ap2s1)

(1) TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.
Santoro et al. Neuron (2009)

Other switches involving participants
AP-2 complex subunit sigma (Ap2s1) - 2 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)