About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000534
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the endocytosis motif of Isoform 3 of PEX5-related protein (Pex5l), abrogating binding to AP-2 complex subunit mu (Ap2m1). The motif is present in exon 2, and its absence causes a significant increase in channel density of members from the potassium channel HCN family.

Participants:
(1) Isoform 3 of PEX5-related protein (Pex5l)
(2) AP-2 complex subunit mu (Ap2m1)

Interactions
Context
References

(1) TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.
Santoro et al. Neuron (2009)

See also

Other switches involving participants
AP-2 complex subunit mu (Ap2m1) - 2 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org