Description: Alternative splicing removes the endocytosis motif of Isoform 3 of PEX5-related protein (Pex5l), abrogating binding to AP-2 complex subunit mu (Ap2m1). The motif is present in exon 2, and its absence causes a significant increase in channel density of members from the potassium channel HCN family.
Participants: (1) Isoform 3 of PEX5-related protein (Pex5l) (2) AP-2 complex subunit mu (Ap2m1)
(1) TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.Santoro et al. Neuron (2009)
Other switches involving participantsAP-2 complex subunit mu (Ap2m1) - 2 more (view)Other switches involving interfacesTRG_ENDOCYTIC_2 - 21 more (view)Adaptor complexes medium subunit family - 21 more (view)
