Switch #: SWTI000533

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d), abrogating binding to Importin subunit alpha-1 (KPNA1) and nuclear import. This is due to an 11 amino acid insert encoded by exon 14.

Participants:
(1) Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d)
(2) Importin subunit alpha-1 (KPNA1)

(1) Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.
Srinivasan et al. J. Cell Biol. (1994)

Other switches involving participants
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
Armadillo/beta-catenin-like repeat - 16 more (view)
TRG_NLS_MonoCore_2 - 1 more (view)