Switch #: SWTI000532

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of G protein-activated inward rectifier potassium channel 2 (Kcnj6), abrogating binding to Sorting nexin-27 (Snx27).

Participants:
(1) G protein-activated inward rectifier potassium channel 2 (Kcnj6)
(2) Sorting nexin-27 (Snx27)

(1) A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction.
Lunn et al. Nat. Neurosci. (2007)

Other switches involving participants
Sorting nexin-27 (Snx27) - 1 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)