Switch #: SWTI000541

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the dynein-binding motif of Unconventional myosin-Va (MYO5A), abrogating binding to Dynein light chain 2, cytoplasmic (DYNLL2). DYNLL2 (also known as DLC2) globally protects the tail domains of MYO5A against limited proteolysis.

Participants:
(1) Unconventional myosin-Va (MYO5A)
(2) Dynein light chain 2, cytoplasmic (DYNLL2)

(1) Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein.
Hódi et al. Biochemistry (2006)

(2) The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain.
Wagner et al. Biochemistry (2006)

Other switches involving interfaces
Dynein light chain type 1 - 2 more (view)