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Switch #:
SWTI000542
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the beta-TrCP-binding degron of RE1-silencing transcription factor (REST), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC), and therefore altering the half-life of the variant. Up-regulation of the protein isoform without the degron has been linked to cancer.

Participants:
(1) RE1-silencing transcription factor (REST)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 REST - BTRC

Interfaces
(1) ELM:DEG_SCF_TRCP1_2 motif (1008DEGIHS1013) in RE1-silencing transcription factor (REST)
(2) WD domain, G-beta repeat (301-590) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
Alternative splicing Abrogation of the RE1-silencing transcription factor (REST) DEG_SCF_TRCP1_2 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context
Switch localisation
Inferred: cytosol
References

(1) Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.
Guardavaccaro et al. Nature (2008)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
ELM:DEG_SCF_TRCP1_2 - 2 more (view)


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