Switch #: SWTI000543

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of F-box/WD repeat-containing protein 7 (FBXW7), abrogating binding to Importin subunit alpha-1 (KPNA1). There are two other NLS motifs in the protein, meaning the isoform can still enter the nucleus.

Participants:
(1) F-box/WD repeat-containing protein 7 (FBXW7)
(2) Importin subunit alpha-1 (KPNA1)

(1) A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.
Welcker et al. Curr. Biol. (2004)

Other switches involving participants
F-box/WD repeat-containing protein 7 (FBXW7) - 8 more (view)
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
Armadillo/beta-catenin-like repeat - 16 more (view)
TRG_NLS_MonoCore_2 - 1 more (view)