About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000545
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the di-leucine motif of Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1), abrogating binding to AP-2 complex subunit sigma (AP2S1). Human and mouse have completely different C-termini for SorCS1a (also known as Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1)), with only the human splice variant containing the motif.

Participants:
(1) Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1)
(2) AP-2 complex subunit sigma (AP2S1)

Interactions
Interaction #1 SORCS1 - AP2S1

Interfaces
(1) ELM:TRG_LysEnd_APsAcLL_2 motif (1136DLFLL1140) in Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)

Interaction Regulation
Alternative splicing Abrogation of the Isoform 4 of VPS10 domain-containing receptor SorCS1 (SORCS1) TRG_LysEnd_APsAcLL_2 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction

References

(1) Different motifs regulate trafficking of SorCS1 isoforms.
Nielsen et al. Traffic (2008)

See also

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
Clathrin adaptor complex small chain - 15 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org