Switch #: SWTI000546

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the endocytosis motif of Isoform 2 of VPS10 domain-containing receptor SorCS1 (SORCS1), abrogating binding to AP-2 complex subunit mu (AP2M1). The sequence is conserved in both human and mouse. Different splice variants have different endocytosis motifs.

Participants:
(1) Isoform 2 of VPS10 domain-containing receptor SorCS1 (SORCS1)
(2) AP-2 complex subunit mu (AP2M1)

(1) Different motifs regulate trafficking of SorCS1 isoforms.
Nielsen et al. Traffic (2008)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)