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Alternative splicing removes the ITSM (immunoreceptor tyrosine-based switch motif) motif of SLAM family member 7 (SLAMF7), abrogating binding to SH2 domain-containing protein 1A (SH2D1A). The full-length isoform (Isoform CS1-L of SLAM family member 7 (SLAMF7)) has 2 ITSM motifs and only one is missing in the shorter splice variant (Isoform 19A24 of SLAM family member 7 (SLAMF7)). However, experiments showed only Isoform CS1-L of SLAM family member 7 (SLAMF7) binds to SH2D1A.

(1) SLAM family member 7 (SLAMF7)
(2) SH2 domain-containing protein 1A (SH2D1A)

Interaction #1 SLAMF7 - SH2D1A

(1) LIG_TYR_ITSM motif (280ENTEYDTI287) in SLAM family member 7 (SLAMF7)
(2) SH2 domain (6-104) in SH2 domain-containing protein 1A (SH2D1A)

Interaction Regulation
Alternative splicing Abrogation of the SLAM family member 7 (SLAMF7) LIG_TYR_ITSM motif - SH2 domain-containing protein 1A (SH2D1A) SH2 domain interaction

Switch localisation
ELM curated: cytosol

(1) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs.
Lee et al. Eur. J. Immunol. (2004)

See also

Other switches involving participants
SH2 domain-containing protein 1A (SH2D1A) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITSM - 4 more (view)

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