Switch #: SWTI000547

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the ITSM (immunoreceptor tyrosine-based switch motif) motif of SLAM family member 7 (SLAMF7), abrogating binding to SH2 domain-containing protein 1A (SH2D1A). The full-length isoform (Isoform CS1-L of SLAM family member 7 (SLAMF7)) has 2 ITSM motifs and only one is missing in the shorter splice variant (Isoform 19A24 of SLAM family member 7 (SLAMF7)). However, experiments showed only Isoform CS1-L of SLAM family member 7 (SLAMF7) binds to SH2D1A.

Participants:
(1) SLAM family member 7 (SLAMF7)
(2) SH2 domain-containing protein 1A (SH2D1A)

(1) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs.
Lee et al. Eur. J. Immunol. (2004)

Other switches involving participants
SH2 domain-containing protein 1A (SH2D1A) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITSM - 4 more (view)