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Switch #:
SWTI000554
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Latent membrane protein 2 (LMP2), abrogating binding to E3 ubiquitin-protein ligase Itchy (Itch).

Participants:
(1) Latent membrane protein 2 (LMP2)
(2) E3 ubiquitin-protein ligase Itchy (Itch)

Interactions
Interaction #1 LMP2 - Itch

Interfaces
(1) LIG_WW_1 motif (98PPPY101) in Latent membrane protein 2 (LMP2)
(2) WW domain (319-352) in E3 ubiquitin-protein ligase Itchy (Itch)

Interaction Regulation
Alternative splicing Abrogation of the Latent membrane protein 2 (LMP2) LIG_WW_1 motif - E3 ubiquitin-protein ligase Itchy (Itch) WW domain interaction

Context
References

(1) NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.
Morales et al. Structure (2007)

See also

Other switches involving participants
Latent membrane protein 2 (LMP2) - 2 more (view)
E3 ubiquitin-protein ligase Itchy (Itch) - 3 more (view)

Other switches involving interfaces
WW domain - 105 more (view)
LIG_WW_1 - 17 more (view)




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