Switch #: SWTI000554

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Latent membrane protein 2 (LMP2), abrogating binding to E3 ubiquitin-protein ligase Itchy (Itch).

Participants:
(1) Latent membrane protein 2 (LMP2)
(2) E3 ubiquitin-protein ligase Itchy (Itch)

(1) NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.
Morales et al. Structure (2007)

Other switches involving participants
Latent membrane protein 2 (LMP2) - 2 more (view)
E3 ubiquitin-protein ligase Itchy (Itch) - 3 more (view)

Other switches involving interfaces
WW domain - 105 more (view)
LIG_WW_1 - 17 more (view)