Switch #: SWTI000559

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).

Participants:
(1) Trem-like transcript 1 protein (TREML1)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

(1) Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
Barrow et al. J. Immunol. (2004)

Other switches involving participants
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)
Trem-like transcript 1 protein (TREML1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITIM - 9 more (view)