Switch #: SWTI000563

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the cyclin-dependent kinase (CDK) phosphorylation motif of Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2), abrogating binding to Cyclin-dependent kinase 1 (CDK1). This phosphorylation is required for the recruitment of Serine/threonine-protein kinase PLK1 (PLK1). The C-terminal extension of Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2) has the ability to distinctly localise to mother centriole whereas the splice variant (e.g. Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2)), which does not have this extension, permits ODF2 to associate with sperm tail.

Participants:
(1) Isoform Cenexin 1 of Outer dense fiber protein 2 (ODF2)
(2) Cyclin-dependent kinase 1 (CDK1)

(1) Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.
Soung et al. Dev. Cell (2009)

Other switches involving participants
Cyclin-dependent kinase 1 (CDK1) - 1 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_CDK_1 - 3 more (view)