Switch #: SWTI000568

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the mitochondrial localisation signal (MLS) motif of tRNA dimethylallyltransferase, mitochondrial (Trit1), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A). The IPPT-I isoform (also known as Isoform 1 of tRNA dimethylallyltransferase, mitochondrial (Trit1)) was found to localise to both the mitochondria and the cytosol whereas the IPPT-II isoform (also known as Isoform 2 of tRNA dimethylallyltransferase, mitochondrial (Trit1)) is only localised to the cytosol and the nucleus. No nuclear localisation signal (NLS) was identified in either splice variant.

Participants:
(1) tRNA dimethylallyltransferase, mitochondrial (Trit1)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

(1) Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol.
Boguta et al. Mol. Cell. Biol. (1994)

Other switches involving participants
Mitochondrial import receptor subunit TOM70 (TOMM70A) - 7 more (view)

Other switches involving interfaces
ELM:TRG_MLS - 7 more (view)
Tetratricopeptide repeat - 8 more (view)