Switch #: SWTI000575

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of Protein PML (PML), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus.

Participants:
(1) Protein PML (PML)
(2) Importin subunit alpha-1 (KPNA1)

(1) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Fagioli et al. Oncogene (1992)

(2) SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.
Duprez et al. J. Cell. Sci. (1999)

(3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.
Jul-Larsen et al. BMC Mol. Biol. (2010)

Other switches involving participants
Protein PML (PML) - 9 more (view)
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
Armadillo/beta-catenin-like repeat - 16 more (view)
ELM:TRG_NLS - 1 more (view)