About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000575
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear localisation signal (NLS) of Protein PML (PML), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus.

Participants:
(1) Protein PML (PML)
(2) Importin subunit alpha-1 (KPNA1)

Interactions
Interaction #1 PML - KPNA1

Interfaces
(1) ELM:TRG_NLS motif (476KRKCSQTQCPRKVIK490) in Protein PML (PML)
(2) Armadillo/beta-catenin-like repeat (115-451) in Importin subunit alpha-1 (KPNA1)

Interaction Regulation
Alternative splicing Abrogation of the Protein PML (PML) TRG_NLS motif - Importin subunit alpha-1 (KPNA1) Armadillo/beta-catenin-like repeat interaction

Context
Switch localisation
Curated: cytosol
References

(1) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Fagioli et al. Oncogene (1992)

(2) SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.
Duprez et al. J. Cell. Sci. (1999)

(3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.
Jul-Larsen et al. BMC Mol. Biol. (2010)

See also

Other switches involving participants
Protein PML (PML) - 9 more (view)
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
Armadillo/beta-catenin-like repeat - 16 more (view)
ELM:TRG_NLS - 1 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org