Switch #: SWTI000592

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3) is expressed at the leading edge of membrane ruffles. The interaction of CLCN3 with SLC9A3R1 is important for localising outwardly rectifying chloride channels at the leading edge.

Participants:
(1) Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

(1) ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC.
Ogura et al. FASEB J. (2002)

Other switches involving participants
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)