Switch #: SWTI000602

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PTB domain-binding motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c), abrogating binding to Talin-1 (Tln1). Integrin receptors, Tln1 and Isoform PIPKIgamma661 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) (PIPKIgamma661) are recruited to focal adhesions, inducing synthesis of PI(4,5)P2. The regulated and localised generation of PI(4,5)P2 facilitates the assembly and/or disassembly of focal adhesions.

Participants:
(1) Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c)
(2) Talin-1 (Tln1)

(1) Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.
Ling et al. Nature (2002)

(2) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.
Di Paolo et al. Nature (2002)

(3) Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage.
Thieman et al. J. Biol. Chem. (2009)

Other switches involving participants
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) - 5 more (view)
Talin-1 (Tln1) - 2 more (view)

Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
ELM:LIG_PTB_Talin - 3 more (view)