Switch #: SWTI000603

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S645 in the PTB-binding motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with Talin-1 (Tln1).

Participants:
(1) Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c)
(2) Talin-1 (Tln1)

(1) Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage.
Thieman et al. J. Biol. Chem. (2009)

(2) Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.
Nakano-Kobayashi et al. EMBO J. (2007)

Other switches involving participants
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) - 5 more (view)
Talin-1 (Tln1) - 2 more (view)

Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
ELM:LIG_PTB_Talin - 3 more (view)