Switch #: SWTI000604

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y644 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) promotes its association with Talin-1 (Tln1).

Participants:
(1) Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c)
(2) Talin-1 (Tln1)

(1) Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases.
Lee et al. J. Cell Biol. (2005)

(2) Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
Ling et al. J. Cell Biol. (2003)

(3) Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin.
Kong et al. J. Mol. Biol. (2006)

Other switches involving participants
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) - 5 more (view)
Talin-1 (Tln1) - 2 more (view)

Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
ELM:LIG_PTB_Talin - 3 more (view)