Switch #: SWTI000608

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of E3 ubiquitin-protein ligase Mdm2 (MDM2), abrogating binding to Exportin-1 (XPO1).

Participants:
(1) E3 ubiquitin-protein ligase Mdm2 (MDM2)
(2) Exportin-1 (XPO1)

(1) MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.
Bartel et al. Mol. Cancer Res. (2004)

(2) MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal.
Schuster et al. Mol. Cancer Res. (2007)

Other switches involving participants
Exportin-1 (XPO1) - 7 more (view)
E3 ubiquitin-protein ligase Mdm2 (MDM2) - 3 more (view)

Other switches involving interfaces
Exportin 1-like protein - 9 more (view)
ELM:TRG_NES_CRM1_2 - 3 more (view)