Switch #: SWTI000609

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of Catenin delta-1 (CTNND1), abrogating binding to Exportin-1 (XPO1). Despite demonstration of the importance of the NES for removing Catenin delta-1 (CTNND1) from the nucleus, those isoforms without NES are rarely found in the nucleus.

Participants:
(1) Catenin delta-1 (CTNND1)
(2) Exportin-1 (XPO1)

(1) Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression.
van Hengel et al. Proc. Natl. Acad. Sci. U.S.A. (1999)

Other switches involving participants
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
TRG_NES_CRM1_1 - 3 more (view)
Exportin 1-like protein - 9 more (view)