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Switch #:
SWTI000610
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of Nuclear factor erythroid 2-related factor 1 (NFE2L1), abrogating binding to Exportin-1 (XPO1). Only the full-length variant of NFE2L1 (Isoform 1 of Nuclear factor erythroid 2-related factor 1 (NFE2L1)) contains an NES and shows cytoplasmic localisation. The two other naturally occuring isoforms (of which at present only 1 is annotated in UniProtKB) lack the NES and show exclusive nuclear staining.

Participants:
(1) Nuclear factor erythroid 2-related factor 1 (NFE2L1)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 NFE2L1 - XPO1

Interfaces
(1) ELM:TRG_NES_CRM1_2 motif (251LSLEECLRL259) in Nuclear factor erythroid 2-related factor 1 (NFE2L1)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the Nuclear factor erythroid 2-related factor 1 (NFE2L1) TRG_NES_CRM1_2 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context
Switch localisation
Curated: nucleus
References

(1) Cellular localisation and nuclear export of the human bZIP transcription factor TCF11.
Husberg et al. Biochim. Biophys. Acta (2003)

See also

Other switches involving participants
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
Exportin 1-like protein - 9 more (view)
ELM:TRG_NES_CRM1_2 - 3 more (view)


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