Description: Alternative splicing removes the PDZ-binding motif of Isoform BAIAP2-alpha of Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2), abrogating binding to Disks large homolog 3 (DLG3). The SH3 domain of Isoform BAIAP2-alpha of Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) also binds to SH3 and multiple ankyrin repeat domains protein 1 (SHANK1), meaning it can link two prominent proteins of the postsynaptic NMDA-receptor complex, namely SHANK1 and DLG3.
Participants: (1) Isoform BAIAP2-alpha of Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) (2) Disks large homolog 3 (DLG3)
(1) Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.Soltau et al. J. Neurochem. (2004)
Other switches involving participantsDisks large homolog 3 (DLG3) - 4 more (view)Other switches involving interfacesPDZ domain (Also known as DHR or GLGF) - 45 more (view)LIG_PDZ_Class_1 - 41 more (view)
