Switch #: SWTI000612

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the IQ motif of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d) abrogating binding to Calmodulin (Calm1). CaV1.3IQdelta (IQ-deleted Isoform CACN4B of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) channels exhibit a lack of calcium-dependent inactivation. CaV1.3IQdelta channel immunoreactivity was preferentially localised to cochlear outer hair cells (OHCs), whereas that of CaV1.3IQfull channels (IQ-possessing Isoform CACN4A of Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)) labelled inner hair cells (IHCs).

Participants:
(1) Voltage-dependent L-type calcium channel subunit alpha-1D (Cacna1d)
(2) Calmodulin (Calm1)

(1) Alternative splicing of the Ca(v)1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells.
Shen et al. J. Neurosci. (2006)

(2) Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels.
Tan et al. J. Biol. Chem. (2011)

Other switches involving participants
Calmodulin (Calm1) - 2 more (view)

Other switches involving interfaces
EF-hand domain pair - 5 more (view)
LIG_IQ - 2 more (view)