Switch #: SWTI000623

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y185 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).

Participants:
(1) Disabled homolog 1 (Dab1)
(2) Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

(1) Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions.
Gao et al. (2012)

Other switches involving participants
Disabled homolog 1 (Dab1) - 10 more (view)
Neuronal proto-oncogene tyrosine-protein kinase Src (Src) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)