Switch #: SWTI000624

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y198 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).

Participants:
(1) Disabled homolog 1 (Dab1)
(2) Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

(1) Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions.
Gao et al. (2012)

(2) Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
Keshvara et al. J. Biol. Chem. (2001)

Other switches involving participants
Disabled homolog 1 (Dab1) - 10 more (view)
Neuronal proto-oncogene tyrosine-protein kinase Src (Src) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_SRC - 8 more (view)