Switch #: SWTI000630

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform Kalirin-7 of Kalirin (Kalrn), abrogating binding to Disks large homolog 4 (Dlg4). Isoform Kalirin-7 of Kalirin (Kalrn) is the most prevalent isoform in the adult rat hippocampus where it locates to the postsynaptic density via an interaction with Dlg4 and regulates dendritic morphogenesis.

Participants:
(1) Isoform Kalirin-7 of Kalirin (Kalrn)
(2) Disks large homolog 4 (Dlg4)

(1) The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis.
Penzes et al. Neuron (2001)

(2) Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons.
Ma et al. J. Neurosci. (2008)

Other switches involving participants
Isoform Kalirin-7 of Kalirin (Kalrn) - 2 more (view)
Disks large homolog 4 (Dlg4) - 2 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)