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Alternative splicing removes the PDZ-binding motif of Isoform Kalirin-7 of Kalirin (Kalrn), abrogating binding to Disks large homolog 4 (Dlg4). Isoform Kalirin-7 of Kalirin (Kalrn) is the most prevalent isoform in the adult rat hippocampus where it locates to the postsynaptic density via an interaction with Dlg4 and regulates dendritic morphogenesis.

(1) Isoform Kalirin-7 of Kalirin (Kalrn)
(2) Disks large homolog 4 (Dlg4)

Interaction #1 Kalrn - Dlg4

(1) LIG_PDZ_Class_1 motif (1649PFSTYV1654) in Isoform Kalirin-7 of Kalirin (Kalrn)
(2) PDZ domain (Also known as DHR or GLGF) (313-393) in Disks large homolog 4 (Dlg4)

Interaction Regulation
Alternative splicing Abrogation of the Isoform Kalirin-7 of Kalirin (Kalrn) LIG_PDZ_Class_1 motif - Disks large homolog 4 (Dlg4) PDZ domain (Also known as DHR or GLGF) interaction


(1) The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis.
Penzes et al. Neuron (2001)

(2) Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons.
Ma et al. J. Neurosci. (2008)

See also

Other switches involving participants
Isoform Kalirin-7 of Kalirin (Kalrn) - 2 more (view)
Disks large homolog 4 (Dlg4) - 2 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)

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