Switch #: SWTI000634

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1), abrogating binding to Disks large homolog 4 (DLG4). Binding of the PDZ domain of DLG4 suppresses an ER-retention motif in GRIN1, promoting its cell surface expression in a splice variant-specific manner.

Participants:
(1) Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)
(2) Disks large homolog 4 (DLG4)

(1) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.
Standley et al. Neuron (2000)

Other switches involving participants
Disks large homolog 4 (DLG4) - 7 more (view)
Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)