Switch #: SWTI000635

Switch type: Specificity

Switch subtype: Motif hiding

Description:
Binding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.

Participants:
(1) Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)
(2) Disks large homolog 4 (DLG4)
(3) Coatomer subunit beta (COPB1)

(1) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.
Standley et al. Neuron (2000)

Other switches involving participants
Coatomer subunit beta (COPB1) - 8 more (view)
Disks large homolog 4 (DLG4) - 7 more (view)
Isoform 4 of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) - 5 more (view)

Other switches involving interfaces
TRG_ER_diArg_1 - 7 more (view)
Adaptin N terminal region - 8 more (view)
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)