Switch #: SWTI000655

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1). Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) interacts specifically with a protein complex including Slc9a3r1 and Ezrin (Ezr) that might participate in its targeting to specialised subcellular regions, such as microvilli.

Participants:
(1) Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1)

(1) New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.
Joubert et al. J. Cell. Sci. (2004)

Other switches involving participants
Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) - 2 more (view)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1) - 2 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)