Switch #: SWTI000656

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the SH2-binding motif of Receptor tyrosine-protein kinase erbB-4 (ERBB4), abrogating binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1). The SH2-binding motif overlaps with a WW-binding motif. Binding of these motifs is regulated in a phosphorylation-dependent manner, ensuring ERBB4 is either endocytosed or stabilised.

Participants:
(1) Receptor tyrosine-protein kinase erbB-4 (ERBB4)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

(1) EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity.
Fan et al. Biochem. J. (2005)

Other switches involving participants
Receptor tyrosine-protein kinase erbB-4 (ERBB4) - 4 more (view)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) - 6 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)