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Switch #:
SWTI000656
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the SH2-binding motif of Receptor tyrosine-protein kinase erbB-4 (ERBB4), abrogating binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1). The SH2-binding motif overlaps with a WW-binding motif. Binding of these motifs is regulated in a phosphorylation-dependent manner, ensuring ERBB4 is either endocytosed or stabilised.

Participants:
(1) Receptor tyrosine-protein kinase erbB-4 (ERBB4)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Interactions
Interaction #1 ERBB4 - PIK3R1

Interfaces
(1) ELM:LIG_SH2_IIA motif (1056YTPM1059) in Receptor tyrosine-protein kinase erbB-4 (ERBB4)
(2) SH2 domain (624-718) in Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Interaction Regulation
Alternative splicing Abrogation of the Receptor tyrosine-protein kinase erbB-4 (ERBB4) LIG_SH2_IIA motif - Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) SH2 domain interaction

Context
References

(1) EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity.
Fan et al. Biochem. J. (2005)

See also

Other switches involving participants
Receptor tyrosine-protein kinase erbB-4 (ERBB4) - 4 more (view)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) - 6 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)




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