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Switch #:
SWTI000663
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Acetylation of K37 in Small ubiquitin-related modifier 1 (SUMO1) inhibits binding to E3 SUMO-protein ligase PIAS1 (PIAS1). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) E3 SUMO-protein ligase PIAS1 (PIAS1)
(2) Small ubiquitin-related modifier 1 (SUMO1)

Interactions
Context
Switch localisation
References

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)

See also

Other switches involving participants
Small ubiquitin-related modifier 1 (SUMO1) - 6 more (view)
E3 SUMO-protein ligase PIAS1 (PIAS1) - 2 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)




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