Switch #: SWTI000664

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Acetylation of K33 in Small ubiquitin-related modifier 2 (SUMO2) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. An additional interaction is also possible upon acetylation with the Bromodomain of p300 shown to bind the acetylated version of SUMO2. This does not occur with acetylated SUMO1. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) E3 SUMO-protein ligase PIAS2 (PIAS2)
(2) Small ubiquitin-related modifier 2 (SUMO2)

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)

Other switches involving participants
Small ubiquitin-related modifier 2 (SUMO2) - 3 more (view)
E3 SUMO-protein ligase PIAS2 (PIAS2) - 1 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)