Switch #: SWTI000665

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Acetylation of K37 in Small ubiquitin-related modifier 1 (SUMO1) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) E3 SUMO-protein ligase PIAS2 (PIAS2)
(2) Small ubiquitin-related modifier 1 (SUMO1)

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)

Other switches involving participants
Small ubiquitin-related modifier 1 (SUMO1) - 6 more (view)
E3 SUMO-protein ligase PIAS2 (PIAS2) - 1 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)