Description: Participants: Interactions ![]() 1Interaction #1 ESR2 - GSK3B Interfaces (1) MOD_GSK3_1 motif (5NSPSSLNS12) in Estrogen receptor beta (ESR2) (2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B) Interaction Regulation PTM-dependent Induction (Phosphorylation of S12 on Estrogen receptor beta (ESR2)) of the Estrogen receptor beta (ESR2) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction 2Interaction #2 ESR2 - UBE2I Interfaces (3) ELM:MOD_SUMO_PHOS motif (4KNSP7) in Estrogen receptor beta (ESR2) (4) Ubiquitin-conjugating enzyme (8-152) in SUMO-conjugating enzyme UBC9 (UBE2I) Interaction Regulation PTM-dependent Induction (Phosphorylation of S6 on Estrogen receptor beta (ESR2)) of the Estrogen receptor beta (ESR2) MOD_SUMO_PHOS motif - SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme interaction Context References (1) Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β. See also Other switches involving participants |
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