Switch #: SWTI000669

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Sumoylation of K4 in Estrogen receptor beta (ESR2) is inhibited by ubiquitination K4. This destabilises ESR2 increasing its turnover (see also switch details)

Participants:
(1) Estrogen receptor beta (ESR2)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)

(1) Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β.
Picard et al. Mol. Cell. Biol. (2012)

Other switches involving participants
Estrogen receptor beta (ESR2) - 2 more (view)
SUMO-conjugating enzyme UBC9 (UBE2I) - 8 more (view)

Other switches involving interfaces
Ubiquitin-conjugating enzyme - 8 more (view)
ELM:MOD_SUMO_PHOS - 1 more (view)