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Switch #:
Switch type:
Switch subtype:
Physicochemical compatibility

Sumoylation of K4 in Estrogen receptor beta (ESR2) is inhibited by ubiquitination K4. This destabilises ESR2 increasing its turnover (see also switch details)

(1) Estrogen receptor beta (ESR2)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)

Interaction #1 ESR2 - UBE2I

(1) ELM:MOD_SUMO_PHOS motif (4KNSP7) in Estrogen receptor beta (ESR2)
(2) Ubiquitin-conjugating enzyme (8-152) in SUMO-conjugating enzyme UBC9 (UBE2I)

Interaction Regulation
PTM-dependent Inhibition (MOD:00492 at K4 on Estrogen receptor beta (ESR2)) of the Estrogen receptor beta (ESR2) MOD_SUMO_PHOS motif - SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme interaction


(1) Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β.
Picard et al. Mol. Cell. Biol. (2012)

See also

Other switches involving participants
Estrogen receptor beta (ESR2) - 2 more (view)
SUMO-conjugating enzyme UBC9 (UBE2I) - 8 more (view)

Other switches involving interfaces
Ubiquitin-conjugating enzyme - 8 more (view)
ELM:MOD_SUMO_PHOS - 1 more (view)

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