Description: Binding of the second KEN-box motif of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), a subunit of the Spindle Assembly Checkpoint (SAC), to the substrate recruitment site of Cell division cycle protein 20 homolog (CDC20), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), blocks binding of the Cdc20 substrate Securin (PTTG1). As a result, Securin (PTTG1) is not targeted for proteasomal degradation until metaphase, when the SAC is inhibited. Destruction of Securin (PTTG1) is required for progression to the anaphase of the cell cycle.
Participants: (1) Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) (2) Cell division cycle protein 20 homolog (CDC20) (3) Securin (PTTG1)
(1) BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.Lara-Gonzalez et al. J. Cell. Sci. (2011)
Other switches involving participantsCell division cycle protein 20 homolog (CDC20) - 3 more (view)Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) - 1 more (view)Other switches involving interfacesWD domain, G-beta repeat - 36 more (view)DEG_APCC_KENBOX_2 - 5 more (view)DEG_APCC_DBOX_1 - 1 more (view)
