Description:
Phosphorylation of S136 in Bcl2 antagonist of cell death (Bad) by RAC-alpha serine/threonine-protein kinase (Akt1) in response to survival and growth signals such as Interleukin-3 (Il3) induces binding to 14-3-3 protein theta (Ywhaq). Binding of 14-3-3 protein theta (Ywhaq) results in dissociation of Bcl2 antagonist of cell death (Bad) from Bcl-2-like protein 1 (Bcl2l1), and thereby inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad) by allowing liberated Bcl-2-like protein 1 (Bcl2l1) to exert its anti-apoptotic effect on pro-apoptotic proteins like Apoptosis regulator BAX (Bax).
Participants:
(1) Bcl2 antagonist of cell death (Bad)
(2) 14-3-3 protein theta (Ywhaq)
Interaction #1 Bad -
YwhaqInterfaces (1) LIG_14-3-3_1 motif (
133RSRSAP138) in
Bcl2 antagonist of cell death (Bad)(2) 14-3-3 protein (3-236) in
14-3-3 protein theta (Ywhaq)Interaction Regulation PTM-dependent Induction (Phosphorylation of
S136 on
Bcl2 antagonist of cell death (Bad)) of the
Bcl2 antagonist of cell death (Bad) LIG_14-3-3_1 motif -
14-3-3 protein theta (Ywhaq) 14-3-3 protein interaction
Regulatory Enzymes for switchModifying enzymes for residue:
S136:
RAC-alpha serine/threonine-protein kinase (Akt1)Inferred Regulatory Enzymes for switchPutative modifying enzymes for residue:
S136 : PKB_group,
RAC-alpha serine/threonine-protein kinase (AKT1),
RAC-alpha serine/threonine-protein kinase (Akt1),
Serine/threonine-protein kinase PAK 1 (PAK1),
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA),
cAMP-dependent protein kinase catalytic subunit alpha (Prkaca),
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA),
Serine/threonine-protein kinase pim-1 (Pim1),
Serine/threonine-protein kinase pim-1 (PIM1),
Serine/threonine-protein kinase pim-2 (PIM2),
Serine/threonine-protein kinase pim-3 (Pim3),
Serine/threonine-protein kinase pim-3 (PIM3),
Ribosomal protein S6 kinase alpha-1 (RPS6KA1).
(1) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Zha et al. Cell (1996)
(2) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
Datta et al. Cell (1997)
(3) How BAD phosphorylation is good for survival.
et al. Nat. Cell Biol. (1999)
(4) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
Datta et al. Mol. Cell (2000)
Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_1 - 13 more (view)
