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Switch #:
SWTI000698
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

Interactions
Interaction #1 EGFR - PLCG1

Interfaces
(1) LIG_SH2_SRC motif (1016YLIP1019) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (550-639) and (668-741) in 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_SRC motif - 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1016 : Tyrosine-protein kinase ABL1 (ABL1), Epidermal growth factor receptor (EGFR), Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol


Switch pathways
Curated: ErbB signaling pathway, Calcium signaling pathway
Inferred: HIF-1 signaling pathway
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

See also

Other switches involving participants
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) - 1 more (view)
Epidermal growth factor receptor (EGFR) - 14 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_SRC - 8 more (view)


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