Interaction #1 EGFR - CRK
(1) LIG_SH2_SRC motif (1125YQDP1128) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)
PTM-dependent Induction (Phosphorylation of Y1125 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_SRC motif - Adapter molecule crk (CRK) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1125 : Proto-oncogene tyrosine-protein kinase Src (SRC).
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
Curated: ErbB signaling pathway
(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Other switches involving participants