Interaction #1 EGFR - NCK1
(1) LIG_SH2_SRC motif (1016YLIP1019) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (282-356) in Cytoplasmic protein NCK1 (NCK1)
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_SRC motif - Cytoplasmic protein NCK1 (NCK1) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1016 : Tyrosine-protein kinase ABL1 (ABL1), Epidermal growth factor receptor (EGFR), Proto-oncogene tyrosine-protein kinase Src (SRC).
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
Curated: ErbB signaling pathway
(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Other switches involving participants