Switch #: SWTI000701

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1262 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to Growth factor receptor-bound protein 2 (GRB2).

Participants:
(1) Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Growth factor receptor-bound protein 2 (GRB2)

(1) Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze et al. Mol. Syst. Biol. (2005)

Other switches involving participants
Receptor tyrosine-protein kinase erbB-3 (ERBB3) - 11 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_GRB2 - 6 more (view)