Switch #: SWTI000702

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).

Participants:
(1) Focal adhesion kinase 1 (PTK2)
(2) Neuronal proto-oncogene tyrosine-protein kinase Src (Src)

(1) Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.
Lindfors et al. FEBS Lett. (2011)

Other switches involving participants
Focal adhesion kinase 1 (PTK2) - 3 more (view)
Neuronal proto-oncogene tyrosine-protein kinase Src (Src) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_SRC - 8 more (view)