Description:
Alternative splicing removes the Sumoylation motif (SIM) of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), preventing the sumolyation of Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1). Both the Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) and Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) exert a differential effect upon IL-2 expression. However, the longer isoform, Isoform C-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), has a sumoylation motif and is therefore negatively regulated in a sumolyation-dependent manner.
Participants:
(1) Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)
(1) Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.
Nayak et al. J. Biol. Chem. (2009)
Other switches involving participants
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) - 4 more (view)
SUMO-conjugating enzyme UBC9 (UBE2I) - 8 more (view)
Other switches involving interfaces
MOD_SUMO - 6 more (view)
Ubiquitin-conjugating enzyme - 8 more (view)
