switches.ELM

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Curated inferred

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Calcium/calmodulin-dependent protein kinase type II subunit alpha

Calcium/calmodulin-dependent protein kinase type II subunit alpha (Rattus)

Proto-oncogene tyrosine-protein kinase Src

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Protein

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Evidence

Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A - Homo sapiens
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
Calcium/calmodulin-dependent protein kinase type II subunit alpha - CAMK2A - Rattus norvegicus
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	EGFR_HUMAN	1069	1074	Cumulative	Rheostatic	While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_TKB	SPY2_HUMAN	55	60	Binary	Physicochemical compatibility	Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred
LIG_TKB	SPY2_HUMAN	55	60	Binary	Physicochemical compatibility	Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).	details	Inferred