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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: ELM:LIG_TKB (6 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
EndocytosisErbB signaling pathwayJak-STAT signaling pathway


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Endocytosis (KEGG - hsa04144)
LIG_TKB EGFR_HUMAN10691074BinaryPhysicochemical compatibilityPhosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred

ErbB signaling pathway (KEGG - hsa04012)
LIG_TKB EGFR_HUMAN10691074BinaryPhysicochemical compatibilityPhosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB EGFR_HUMAN10691074CumulativeRheostaticWhile phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred

Jak-STAT signaling pathway (KEGG - hsa04630)
LIG_TKB SPY2_HUMAN5560BinaryPhysicochemical compatibilityPhosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
LIG_TKB SPY2_HUMAN5560CumulativeRheostaticWhile phosphorylation of Y55 induces binding, additional phosphorylation of T56 in the TKB-binding motif of Protein sprouty homolog 2 (SPRY2) lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL).
details
Inferred
           
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