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Switch #:
Switch type:
Switch subtype:
Physicochemical compatibility

Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL).

(1) Epidermal growth factor receptor (EGFR)
(2) E3 ubiquitin-protein ligase CBL (CBL)

Interaction #1 EGFR - CBL

(1) ELM:LIG_TKB motif (1069YSSDPT1074) in Epidermal growth factor receptor (EGFR)
(2) E3 ubiquitin-protein ligase CBL (CBL)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1069 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_TKB motif - E3 ubiquitin-protein ligase CBL (CBL) interaction

Additional Information
Affinity : pY1069: 1.0 µM
Structural information: 3OB2
Switch localisation

Switch pathways

(1) Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.
Sun et al. PLoS ONE (2010)

See also

Other switches involving participants
E3 ubiquitin-protein ligase CBL (CBL) - 4 more (view)
Epidermal growth factor receptor (EGFR) - 14 more (view)

Other switches involving interfaces
ELM:LIG_TKB - 3 more (view)
IPR:IPR024159 - 3 more (view)

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