Switch #: SWTI000012

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).

Participants:
(1) Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
(2) Glycogen synthase kinase-3 beta (GSK3B)

(1) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
Sheridan et al. J. Biol. Chem. (2002)

Other switches involving participants
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) - 4 more (view)
Glycogen synthase kinase-3 beta (GSK3B) - 18 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_GSK3_1 - 18 more (view)